Michael Fill, Ph.D.                                                                                     November, 2006

                                                             

Title:               Professor

Address:         Rush University Medical Center,

                        Department of Molecular Biophysics and Physiology

                        1750 West Harrison Street

                        Chicago, IL 60112

Ph.  #:              +1 312 942 6434

Fax #:              +1 312 942 8711

Email:             michael_fill@rush.edu

 

EDUCATION:

1978-82                     School of Life Sciences BS                   University of Illinois, Urbana

                        1982-84           Physiology & Biophysics           MS                  University of Illinois, Urbana

                        1984-87           Physiology & Biophysics           PhD                 University of Illinois, Urbana

 

PROFESSIONAL POSITIONS:

1987-1989             Postdoctoral Fellow; Baylor College of Medicine, Houston TX

1990-1994             Assistant Professor, Dept. Physiology, University of Texas, Galveston, TX

1994-1995             Associate Professor (w/ tenure), Dept. Physiology, University of Texas, Galveston, TX

1995-1998             Associate Professor, Dept. Physiology, Loyola University Chicago, Maywood, IL

1998-2005             Associate Professor (w/ tenure), Loyola University Chicago, Maywood, IL

2005-present    Professor (w/tenure), Rush University Medical Center, Chicago, IL

 

HONORS & DISTINCTIONS:

USPHS Pre-doctoral Trainee (1984, 1985, 1986, 1987)

MDA & NIH Postdoctoral Fellowships (1988, 1989, 1990)

Sealy Foundation Research Grant (1991-1993; 1 award)

AHA Established Investigator (1994-1999; 1 award as P.I.)

Member, AHA Grant Review Committee (1993-1998)

Member NIH Study Section (Physiology; 1997)

Member NIH Study Section (MDCN-4; 1998-2003)

Invited Speaker, Gordon Research Conference (1991-2003; 7 times)

Session Organizer, Gordon Research Conference (1994)

Awarded Tenure at University of Texas, Galveston TX (1994)

Awarded Tenure at Loyola University Chicago, Maywood IL (1998)

Invited Pathophysiology Lecture, Stanford University (“Malignant Hyperthermia"; 1993)

Invited Speaker, NATO Research Workshop on “Intracellular Ca Signaling”, Il Ciocco, Italy (2000)

Top Science Poster Award, Biophysical Society of Latin American (SOBLA), Alicante, Spain (2000)

Member Advisory Committee, National Lab of Fluorescence Dynamics, Urbana, IL (2001-2002)

Organizer, International Ca Signaling Workshop, Buenos Aries, Argentina (2002)

Invited Speaker, International Symposium on Muscle Ca Signaling, Mexico City, Mexico (2003)

Invited Speaker, International Workshop on Ca Signaling, Marbella, Chile (2003)

Member Parent Committee, NIH SCCOR grant program for Cardiac Dysfunction (2004)

 

 

 

 

 

RESEARCH TRAINEES: 

(1)   Current Trainees

                        Yiwie Liu, Neuroscience Graduate Student

                        Jia Qin, Physiology Graduate Student

 

(2)   Past Postdoctoral Fellows

Josefina Ramos-Franco, MD-PhD          Assistant Professor (tenure track), Rush University

Julio A. Copello, PhD,                            Assistant Professor (tenure track), Illinois State Univ., USA

Sandor Gyorke, PhD                              Professor (w/ tenure), Ohio State University, USA

Rafael Mejia-Alvarez, MD-PhD             Assistant Professor (tenure track), Loyola Univ. Chicago, USA Ariel Escobar, PhD                            Assistant Professor (tenure track), Texas Tech Univ., USA

Patricio Velez, PhD                               Associate Professor (w/ tenure), Univ. Valparaiso, CHILE

Xuande Li, PhD                                   Assistant Professor, University Unknown, CHINA

 

(3)   Past Predoctoral Fellows

Patricio Velez, PhD                               PhD Completed/Defended now an Associate Professor

Qiang Tu, PhD                                      PhD Completed/Defended now a Programming Executive

Jimena Sierralta, PhD                            PhD Completed/Defended now an Assistant Professor

Jin Lu, PhD                                           PhD. Completed/Defended now a Postdoctoral Fellow

Alois Sonnleitner, PhD                           Visiting PhD Student now a Postdoctoral Fellow

Mary Elena Zhogbi, PhD                       Visiting PhD Student now a Postdoctoral Fellow

                        Leticia Gomez, Ph.D.                            Visiting PhD Student now a Postdoctoral Fellow
                        Carlos Villalba-Galea, Ph.D.                  Visiting PhD Student now a Postdoctoral Fellow

Sean Caenepeel            , MS                             Masters Student now working at Sugen Biotech.Corp.

 

 

EXTRAMURAL RESEARCH FUNDING:  

(1)   Current Funding

                        NIH R01-HL57832, 07/1997 to 11/2011, P.I.: Fill

                                    "Control Mechanisms of Ca-induced Ca Release in Heart"

NIH R01-HL071741, 07/2003 to 07/2007,  P.I.: Ramos-Franco, Co-I.: Fill

            “Local Intracellular Calcium Release in Neonate Heart”

                                   

(2)   Pending Grants

                        NIH R01-AR054098, Submitted 10/2006: P.I.: Fill

                                    "Skeletal Muscle Ryanodine Receptor Permeation and Self Counter-Ion Flow "

                                                            . 

(3)   Previous Funding

AHA SDG Grant (#0120142N), 01/2001 to 12/2004; P.I.: Copello, Co-I.: Fill

            “Role of Ryanodine Receptor Functional Heterogeneity in EC coupling in Striated Muscle”

MDA RG Grant, 01/2004 to 12/2006, P.I.: Copello, Co-I.: Fill

            “Coordinated Gating of Ryanodine Receptor Channels”   

NIH R01-HL64210, 02/2000 to 01/2005, P.I.: Fill

            "Regulation of Single Calcium Release Channels in Heart"

                        NIH R01-MH53367, 07/1995 to 06/2003, P.I.: Mignery, Co-I: Fill

                                    “Molecular Analysis of InsP3R Structure Function”,

NIH R01-HL58851, 09/1997 to 08/2001, P.I.: Mignery, Co-I: Fill

            “Isoform Specific Function of InsP3R Receptor Channels”,

AHA, National Grant-in-Aid, 01/1999 to 12/2002, P.I.: Mejia-Alvarez, Co-I: Fill                                        “Development of Cardiac E-C Coupling”,

AHA Established Investigatorship, 07/1994 to 06/1999, P.I.: Fill

            "Regulation of SR Ca2+ Release"

MDA, National Grant-in-Aid, 07/1994 to 06/1997, P.I.: Fill

            "Calcium Control of SR Calcium Release"

AHA, National Grant-in-Aid, 07/1994 to 06/1997, P.I.: Fill

            "Calcium Regulation of Cardiac SR Ca2+ Release"

NIH R29-AR41197, 07/1992 to 06/1997, P.I.: Fill

            "Calcium-Dependent Regulation of SR Calcium Release"

NIH R01-NS29640, 04/1992 to 03/1996, P.I.: Christianson, Co-I.: Fill

                                    "Calcium Release Stores in Cerebellar Purkinje Cells"

MDA, National Grant-in-Aid, 01/1992 to 12/1995, P.I.: Fill

            "Regulation of SR Ca2+ Release Channels"

SEALY Foundation Grant, 08/1991 to 07/1993, P.I.: Fill

            "Regulation of Cardiac SR Ca+2 Release Channel"

 

FULL-LENGTH PUBLISHED WORKS:        

1.       Best, P.M. and M. Fill.  Calcium release rate in skinned skeletal muscle fibers measured with arsenazo III.  American Journal of Physiology 250(19): C245‑255, 1986.

2.       Fill, M. and P.M. Best.  Contractile activation and recovery in skinned frog muscle stimulated by ionic substitution. American Journal of Physiology 254(23): C107‑114, 1988.

3.       Fill, M. and R. Coronado.  Ryanodine receptor channel of sarcoplasmic reticulum.  Trends in Neuroscience 11(10): 453‑457, 1988.

4.       Ma J., M. Fill, C. Knudson, K.P. Campbell, R. Coronado.  Ryanodine receptor of skeletal muscle is a gap junction‑type channel. Science 242:99-102, 1988.

5.       Pizarro, G., G. Brum, M. Fill, R. Fitts, M. Rodríguez, I. Uribe, and E. Rios.  Voltage sensor of excitation‑contraction coupling in skeletal muscle: A comparison with Ca channels.  The Calcium Channel, Ed. Kusche, Springer‑Verlag, Berlin, 1988.

6.       Smith, J.S., T. Imagawa, J. Ma, M. Fill, K. Campbell, and R. Coronado.  Purified ryanodine receptor from rabbit skeletal muscle is the calcium‑release channel of the sarcoplasmic reticulum.  Journal of General Physiology 92(1): 1‑26, 1988.

7.       Fill, M. and P.M. Best.  Block of Contracture in Skinned Frog Skeletal Muscle Fibers by Calcium Antagonists. Journal of General Physiology 93(3): 429‑449, 1989

8.       Fill, M., J. Ma, C.M. Knudson, T. Imagawa, K.P. Campbell, and R. Coronado.  Role of the ryanodine receptor of skeletal muscle in Excitation‑ Contraction coupling. Calcium Channels: Structure and Function, Ed. Wray‑Norman‑Hess, The New York Academy of Sciences, New York, 1989

9.       Hamilton, S.L., R. Mejía‑Alvarez, M. Fill, M.J. Hawkes, K. Brush, W.P. Schilling, and E. Stefani.  PN200-110 and ryanodine binding and reconstitution of ion channel activity with skeletal muscle membranes. Analytical Biochemistry, 183: 31‑41, 1989.

10.   Fill, M., R. Coronado, J.R. Mickelson, J.R. Vilven, J.J. Ma, B.A. Jacobson, and C.F. Louis.  Abnormal ryanodine receptor channels in  malignant hyperthermia. Biophysical Journal 57(3): 471-475, 1990.

11.   Fill, M. and P.M. Best.  Effects of perchlorate on contractile activation in skinned skeletal muscle fibers.  Pflügers Archive 415(6): 688-692, 1990.

12.   García, J., M. Fill, L. Toro, and E. Stefani. Functional studies of calcium channels from plasmalemma and sarcoplasmic reticulum membranes in muscle cells. Seminars in Cell Biology, Vol. 1, W.B. Saunders Co., pgs. 225-264, 1990.

13.   Mejía‑Alvarez, R., M. Fill and E. Stefani. Voltage dependent inactivation of skeletal muscle T‑tubular calcium channels in planar lipid bilayers. Journal of General Physiology 97: 393-412, 1991.

14.   Fill, M., R. Mejía‑Alvarez, P. Volpe, F. Zorzato, and E. Stefani. Antibodies as probes for ligand gating of single sarcoplasmic reticulum calcium release channels. Biochemical Journal 273: 449-457, 1991.

15.   Fill, M., E. Stefani, and T. Nelson.  Abnormal human ryanodine receptor channels in malignant hyperthermia. Biophysical Journal  59: 1085-1090, 1991.

16.   Shomer, N.H., C.F. Louis, M. Fill, L.A. Litterer, and J. Mickelson.  Reconstitution of abnormalities in the malignant hyperthermia-susceptible pig ryanodine receptor.  American Journal of Physiology  264: C125-C135, 1993.

17.   Chu, A., M. Fill, E. Stefani, and M. Entman. Calcium sensitivity of ryanodine receptor channels from cardiac sarcoplasmic reticulum.  Journal of Membrane Biology  135: 49-59, 1993.

18.   Györke, S., and M. Fill.  Ryanodine receptor adaptation:  Control mechanism of Ca2+-induced Ca2+ release in heart.  Science  260: 807-809, 1993.

19.   Györke, S., and M. Fill.  Ca2+-induced Ca2+ release in response to flash photolysis.  Science 263: 987-988, 1994.

20.   Tu, Q., P. Vélez, M. Cortes-Gutierrez and M. Fill.  Surface charge at the lumenal mouth of the cardiac ryanodine receptor channel. Journal of General Physiology 103: 1-15, 1994.

21.   Györke, S., P. Vélez, B. Suárez-Isla, and M. Fill.  Activation of cardiac and skeletal SR Ca2+ release channels by flash photolysis of caged-Ca2+.  Biophysical Journal  66: 1879-1886, 1994.

22.   Tu, Q., P. Vélez, M. Brodwick, and M. Fill.  Streaming potentials reveal a short ryanodine sensitive selectivity filter in cardiac Ca2+ release channel. Biophysical Journal  67: 2280-2285, 1994.

23.   Cheng, H., M. Fill, H. Valdivia and J. Lederer. Models of calcium release channel adaptation.  Science  267: 2009-2010, 1995.

24.   Uehara, A., M. Fill*, P.Velez, M. Yasukochi and I. Imanaga. Rectification of Rabbit Cardiac Ryanodine Receptor Current by Endogenous Polyamines. Biophysical Journal  71(2): 769-777, 1996. (*major contributor)

25.   Sierralta, J., B. Suárez-Isla and M. Fill. Functionally heterogeneous ryanodine receptor channels in Avian Cerebellum. Journal of Biological Chemistry  271(29): 17028-17034, 1996.

26.   Velez P., A.L. Escobar, S. Gyorke, J. Vergara and M. Fill. Adaptation of single ryanodine receptor channels. Biophysical Journal  72(2): 691-697, 1997.

27.   Minn, A.J., P. Velez, S.L. Schendel, H. Liang, S.W. Muchmore, S.W. Fesik, C.B. Thompson* and M. Fill*. Bcl-xl forms an ion channel in synthetic lipid membranes. Nature 385:353-357, 1997. (*co-corresponding senior authors)

28.   Escobar, A.L., P. Vélez, F. Cifuentes, M. Fill, and J. Vergara.  Kinetic properties of DM-Nitrophen and calcium indicators: rapid transient response to flash photolysis. Pflügers Archive 434(5): 615-631, 1997.

29.   Perez, P.J., J. Ramos-Franco, M. Fill and G.A. Mignery. Identification and functional reconstitution of the type-2 InsP3 receptor from ventricular cardiac myocytes. Journal of Biological Chemistry 272(38): 23961-23969, 1997.

30.   Velez, P., R. Mejia-Alvarez and M. Fill. Ryanodine Receptor Adaptation. Structure and Function of Ryanodine Receptors, Imperial College Press, Ed. A. Williams & R. Sitsapesan, Chapter 13, pgs. 253-267, 1997.

31.   Ramos-Franco, J., M. Fill and G.A. Mignery. Isotype Specific Function of Single InsP3 Receptor Channels. Biophysical Journal  75: 834-839, 1998.

32.   Ramos-Franco, J., S. Caenepeel, S., M. Fill and G.A. Mignery. Single Channel Function of Recombinant Type Inositol 1,4,5-Trisphosphate Receptor Ligand Binding Domain Splice Variants. Biophysical Journal  75(6): 2783-2793, 1998.

33.   Bers, M.D. and M. Fill. Coordinated Feet and the Dance of the Ryanodine Receptors. Science  281: 790-791, 1998.

34.   Satoh, H., H. Katoh, P. Velez, M. Fill and D.M. Bers. BayK 8644 increases resting Ca spark frequency in ferret ventricular myocytes independent of Ca influx: contrast with caffeine and ryanodine effects. Circulation Research  83(12): 1192-1204, 1998.

35.   Mejia-Alvarez, R., E. Rios, M. Stern, C. Kettlun and M. Fill. Unitary Ca current through cardiac ryanodine receptor channels under quasi-physiological ionic conditions. Journal of General Physiology  113(2): 177-186, 1999.

36.   Minn, A.J., C. Kettlun, H. Liang, A. Kelekar, M.G. Vander Heiden, B.S. Chang, S.W. Fesik, M. Fill and C.B. Thompson. Bcl-xl regulates apoptosis by heterodimerization-dependent and –independent mechanisms. EMBO Journal 18(3): 632-643, 1999.

37.   Fill, M., R. Mejia-Alvarez, C. Kettlun and A. Escobar. Ryanodine receptor permeation and gating: Glowing cinders that underlie the Ca spark.  Journal of General Physiology  114: 159-161, 1999.

38.   Ramos-Franco, J., D. Galvan, G.A. Mignery and M. Fill. Location of the Permeation Pathway in the Recombinant Type-1 Inositol 1,4,5-trisphosphate Receptor. Journal of General Physiology  114(2):243-250, 1999.

39.   Zoghbi, M.E., P. Balanos, C. Villalba-Galea, A. Marcano, E. Hernandez, M. Fill and A. Escobar. Spatial Ca2+ Distribution in Contracting Striated Muscle Cells. Biophysical Journal 78(1): 164-173, 2000.

40.   Ramos-Franco, J., D. Bare, S. Caenepeel, A. Nani, M. Fill, and G.A. Mignery. Single Channel Function of Recombinant Type-2 Inositol 1,4,5-Trisphosphate Receptor. Biophysical Journal 79: 1388-1399, 2000.

41.   Fill, M., A. Zahradníková*, C.A. Villalba-Galea, I. Zahradník*, A.L. Escobar and S. Györke. Ryanodine Receptor Adaptation. Journal of General Physiology  116:1-11, 2000.

42.   Olson, R.D., X. Li, P. Palade, S.E. Shadle, P.S. Mushlin, H.A. Gambliel, M. Fill, R.J. Boucek and B.J. Cusack.  Sarcoplasmic Reticulum Calcium Release Is Stimulated and Inhibited by Daunorubicin and Daunorubicinol. Toxicology and Applied Pharmacology 169:168-176, 2001.

43.   Fill, M., J. Ramos-Franco and G.A. Mignery. Inositol Trisphosphate Receptor Type-2: The Other Calcium Release Channel in Heart. Calcium Signaling, Series I: Life & Behavioral Sciences – Vol. 331, Eds. Morad & Kostyuk, ISO Press, Washington DC, pgs. 53-61, 2001.

44.   Uehara, A., M. Yasukochi, R. Mejia-Alvarez, M. Fill and I. Imanaga. Gating kinetics and ligand sensitivity modified by phosphorylation of cardiac ryanodine receptors. Pflügers Archive  444(1):202-212, 2002.

45.  Copello, J., S. Barg, A. Sonnleitner, M. Porta, P. Diaz-Sylvester, M. Fill, H. Schindler and S. Fleischer. Differential activation by calcium, ATP and caffeine of cardiac and skeletal muscle ryanodine receptors after block by magnesium. Journal Membrane Biology  187:51-64, 2002.

46.   Fill, M., and J. Copello.  Ryanodine receptor calcium release channels. Physiological Reviews 82(4):893-922, 2002.

47.   Mejia-Alvarez, C. Manno, C.A. Villalba-Galea, L.V. Fernandez, R.R. Costa, M. Fill, T. Gharbi and A. Escobar. Pulsed local-field fluorescence microscopy: A new approach for measuring cellular signals in beating heart. Pflügers Archive 445(6):747-58, 2003.

48.   Fill, M.  Mechanisms that turn-off intracellular calcium release channels. Front. Bioscience 8:46-54, 2003.

49.   Ramos, J., W. Jung, J. Ramos-Franco, G.A. Mignery and M. Fill. Single Channel Function of Inositol 1,4,5-trisphosphate Receptor Type-1 and -2 Isoform Domain-Swap Chimeras. Journal of General Physiology  121(5):399-411, 2003.

50.   Kettlun, C., A. Gonzalez, R. Rios and M. Fill. Unitary Ca2+ current through mammalian and amphibian skeletal muscle ryanodine receptor channels under near physiological ionic conditions. Journal of General Physiology 122(4):407-417, 2003.

51.   Rosales R., A. Escobar and M. Fill. Calcium Regulation of Single Ryanodine Receptor Channel Gating

Analyzed Using HMM/MCMC Statistical Methods. Journal of General Physiology 123(5):533-553, 2004.

52.   Zoghbi M.E., J. Copello, V. Villalba-Galea, P. Velez, P.L. Diaz Sylvester, P. Bolanos, A. Marcano, M. Fill and A.L. Escobar. Differential Ca and Sr regulation of intracellular divalent cations release in ventricular myocytes. Cell Calcium 36(2):119-134, 2004.

53.   Perez C.G., J. Copello, L., Y. Li, K.L. Karko, L. Gomez, J. Ramos-Franco, M. Fill, , A. Escobar and R. Mejia-Alvarez. Ryanodine receptor function in new born rat heart. American Journal of Physiology 288(5):2527-40,  2005.

 

PUBLISHED ABSTRACTS:

1.        Best and Fill.  Federation Proceedings 43:1040, 1984.

2.        Fill and Best.  J. Gen. Physiol. 84:12a, 1984.

3.        Fill and Best.  Biophys. J. 47:291a, 1985.

4.        Fill and Best.  Biophys. J. 49:13a, 1986.

5.        Fill and Best.  Biophys. J.  51:106a, 1987.

6.        Fill, Fitts, Pizarro and Ríos.  Biophys. J.  53:603a, 1988.

7.        Fill, Ma, Campbell, Imagawa, Knudson, Stefani and Coronado. Biophys. J.  53:606a, 1988.

8.        Fill, and Best. Biophys. J. 55:87a, 1989.

9.        Fill, Mejía‑Alvarez, Hamilton, and Stefani.  Biophys. J. 55:297a, 1989.

10.     Fill, Mickelson, Jacobson, Coronado, and Louis.  Biophys. J. 55:85a, 1989.

11.     Fill, Nelson, and Stefani. Biophys. J., 57:278a, 1990.

12.     Fill, Mejía‑Alvarez, Volpe, Zorzato, and Stefani. Biophys. J. 57:170a, 1990.

13.     Chu, FillL. Entman, and Stefani.  Biophys. J.  59:102a, 1991.

14.     Mejía-Alvarez, Fill, García, Nelson, and Stefani.  Biophys. J.  59:271a, 1991.

15.     Tu, and Fill.  Biophys. J.  61:A433, 1992.

16.     Li, Palade, Fill, and Olson. Biophys. J.  61:A432, 1992.

17.     Tu, Vélez, and Fill.  Biophys. J.  64:A304, 1993.

18.     Györke and Fill.  Biophys. J.  64:A380, 1993.

19.     Vélez, Györke, Suárez-Isla and Fill.  Cong. Iberoam. Biofisica,  Puebla, Mexico, 1993.

20.     Sierralta, Fill, and Suárez-Isla.  Cong. Iberoam. Biofisica,  Puebla, Mexico, 1993.

21.     Györke, Vélez, Suárez-Isla and Fill.  Biophys. J. 66(2):417a, 1994.

22.     Tu, Vélez, Brodwick and Fill.  Biophys. J. 66(2):418a, 1994.

23.     Vélez, Tu, Li and Fill.  Biophys. J. 66(2):418a, 1994.

24.     Sierralta, Suárez-Isla and Fill.  Biophys. J. 66(2):147a, 1994.

25.     Vélez, Escobar, Cifuentes, Vergara and Fill.  Biophys. J., 68(2):A375, 1995.

26.     Vélez, Li, Tsushima, Wasserstrom and Fill.  Biophys. J., 68(2):A375, 1995.

27.     Tu, Vélez, Brodwickand Fill.  Biophys. J., 68(2):A375, 1995.

28.     Vélez, Györkeand Fill.  Biophys. J., 68(2):A356, 1995.

29.     Li and Fill.  Biophys. J., 68(2):A376, 1995.

30.     Sierralta, Suárez-Isla, Armisen and Fill.  Biophys. J., 68(2):A383, 1995.

31.     Escobar, Vélez, Cifuentes, Fill and Vergara.  Biophys. J., 68(2):A418, 1995.

32.     Uehara, Velez, Yasukochi and Fill. Biophys. J., 70(2):165a, 1996.

33.     Velez, Escobar, Gyorke, Vergara and Fill. Biophys. J., 70(2):165b, 1996.

34.     Velez, Escobar, Zhogbi, Suarez-Isla and Fill. Biophys. J., 72(2):375a, 1997.

35.     Armisen, Velez, Fill and Suarez-Isla. Biophys. J., 72(2):169a, 1997.

36.     Ramos-Franco, Mignery and Fill. Biophys. J., 72(2):112a, 1997.

37.     Perez, Ramos-Franco, Fill and Mignery. Biophys. J., 72(2):358a, 1997.

38.     Villalba, Suarez-Isla, Fill and Escobar. Biophys.J., 74(2):58a, 1998.

39.     Mejia-Alvarez, Rios, Stern, Kettlun and Fill. Biophys.J., 74(2):58a, 1998.

40.     Suarez-Isla, Armisen, Alcayaga and Fill. Biophys.J., 74(2):59a, 1998.

41.     Ramos-Franco, Perez, Caenepeel, Migenry and Fill. Biophys.J., 74(2):61a, 1998.

42.     Escobar, Zhogbi, Villalba and Fill. Biophys.J., 74(2):271a, 1998.

43.     Mejia-Alvarez, Tgharbi, Gomez, Fill and Escobar. Biophys. J., 76(1):296a, 1999.

44.     Gomez, Escobar, Fill and Mejia-Alvarez. Biophys.J., 76(1):297a, 1999.

45.     Ramos-Franco, Nani, Mignery and Fill. Biophys.J., 76(1):375a, 1999.

46.     Ramos-Franco, Galvan, Borrego-Diaz, Fill and Mignery. Biophys.J., 76(1):375a, 1999.

47.     Kettlun, Suarez-Isla and Fill. Biophys.J., 76(1):304a, 1999.

48.     Kettlun, Gonzalez, Rios and Fill. Biophys. J., 78(1):437a, 2000.

49.     Ramos-Franco, Galvan, Mignery and Fill. Biophys. J., 78(1):313a, 2000.

50.     Ramos-Franco, Bare, Nani, Fill and Mignery. Biophys. J., 78(1):313a, 2000.

51.     Galvan, Fill and Mignery. Biophys. J., 78(1):313a, 2000.

52.     Escobar, Fill and Mejía-Alvarez. Biophys. J., 78(1):98a, 2000.

53.     Escobar, Ribiero-Costa, Villalba, Fill and Mejía-Alvarez. Biophys. J., 78(1):98a, 2000.

54.     Escobar, Villalba-Galea, Fill and Mejia-Alvarez.  Ibero-American Biophysical Society, 2000.

55.     Ramos-Franco, Mignery and Fill. Ibero-American Biophysical Society, 2000

56.     Copello, Perez, Mejia-Alvarez, Escobar and Fill.  Biophys. J. 80(1):385a, 2001.

57.     Perez, Copello, Fill and Mejia-Alvarez. Biophys. J.:596a, 2001.

58.     Ramos-Franco. Galvan, Ramos, Mignery and Fill. Biophys.J.:460a, 2001.

59.     Ramos, Jung, Ramos-Franco, Fill and Mignery. Biophys.J.:460a, 2001.

60.     Ramos-Franco, Galvan, Mignery and Fill.  International NATO Workshop 331:64-65, 2001.

61.     Ramos-Franco, Pérez, Snopko, Li, Fill and Mejía-Alvarez.  Biophys.J.:72a, 2002.

62.     Rosales, Villalba-Galea, Kettlun, Fill and Escobar. Biophys.J.:74a, 2002.

63.     Diaz-Sylvester, Porta, Nani, Escobar, Fill and Copello. Biophys.J.:74a, 2002.

64.     Porta, Diaz-Sylvester, Nani, Villalba-Galea, Rosales, Escobar, Fill and Copello. Biophys.J.:82a, 2002.

65.     Kettlun, Galvan, Fill and Mignery. Biophys.J.:258a, 2002.

66.     Ramos, Escobar, Mignery and Fill. Biophys.J.:640A, 2002.

67.     Escobar, Fill, Nori and Volpe. Biophys.J.:640a, 2002.

68.     Diaz-Sylvester, Porta, Nani, Escobar, Fill and Copello.  Internat.Biophys.Cong. IUPAB, SAB:103a, 2002.

69.     Porta, Nani, Ramos-Franco, Fill, Ikemoto and Copello. Biophysical Society, 2003.

70.     Copello, Porta, Diaz-Sylvester, Nani, Fleischer and Fill.  Biophysical Society, 2003.

71.     Ramos, Escobar, Mignery, Copello and Fill. Biophysical Society, 2003.

72.     Ramos-Franco, Nani, Guo, Copello and Fill. Biophysical Society, 2003.

73.     Fill.  Workshop on calcium signaling, Marbella, Chile, 2003.

74.     Fill and Ramos. Muscle Ca Signaling Symposium, Mexico City, Mexico, 2003.

75.     Kettlun, González, Ríos and Fill. Gordon E-C coupling research conference, 2003.

76.     Liu, Ramos-Franco, Copello, Webber. Jr. and Fill. Society of Neuroscience, 2003.

77.     Ramos, Ramos-Franco, Piedras-Renteria and Fill. Society of Neuroscience, 2003.

78.     Porta,Fleischer, Fill and Copello. Biophysical Society, 2004.

79.     Copello, Porta, Diaz-Sylvester and Fill.  Biophysical Society, 2004.