Publications, 

1975 to 1977  (Univ de la República, Montevideo) 

Castro, J., E. Ríos and C. García.  Characterization of the "Inotropic Effect" produced on a systole by the preceeding ones (in Spanish).  Sístole, Montevideo 26: 36‑47, 1975.

 

Ríos, E., J. Castro and C. García.  The inotropic memory of amphibian myocardium.  I.  Identification of two simultaneous mechanisms and statement of a model.  Arch. Int. Physiol. Biochim. 83: 27‑43, 1975.

 

García, C., E. Ríos, A. Sánchez, E. Alvarez and E. Barrios.  The inotropic memory of amphibian myocardium.  II.  Quantitative verification of a model.  Arch. Int. Physiol. Biochim. 85: 435‑453, 1977.

 

1979 to 1985  (Univ of Rochester, New York) 

Kovács, L. E. Ríos and M.F. Schneider.  Calcium transients and intramembrane charge movement in skeletal muscle fibres.  Nature 279: 391‑396, 1979.

 

Schneider, M.F., E. Ríos, and L. Kovács.  Calcium transients and intramembrane charge movement in skeletal muscle.  In: The Regulation of Muscle Contraction: Excitation‑Contraction Coupling, A.D. Grinnell and M.A.B. Brazier, eds. New York: Academic Press, 1980.

 

Ríos, E. and M.F. Schneider.  Stoichiometry of the reactions of calcium with the metallochromic indicator dyes Antipyrylazo III and Arsenazo III.  Biophys. J., 36: 601‑621, 1981.

 

Kovács, L., E. Ríos and M.F. Schneider.  Measurement and modification of free calcium transients in frog skeletal muscle fibres by a metallochromic indicator dye.  J. Physiol. (London) 343: 161‑196, 1983.

 

Melzer, W., E. Ríos and M.F. Schneider.  Time course of calcium release and removal in skeletal muscle fibers.  Biophys. J., 45: 637‑641, 1984.

 

Schneider, M.F., E. Ríos and W. Melzer.  Use of a metallochromic indicator to study intracellular calcium movements in skeletal muscle.  Cell Calcium 6: 109‑118, 1985.

 

Melzer, W., E. Ríos and Schneider, M.F.  The removal of myoplasmic free calcium

following calcium release in frog skeletal muscle.  J. Physiol.  (London) 373:481‑512, 1986.

 

 

1986 to 1999  (Rush University, Chicago) 

 

Melzer, W., Ríos, E. and Schneider, M.F.  A general procedure for determining calcium release from the sarcoplasmic reticulum in skeletal muscle fibres.  Biophys. J., 51: 849‑864, 1987.

 

Ríos, E. and Brum, G.  Involvement of dihydropyridine receptors in excitation‑ contraction coupling in skeletal muscle.  Nature, 325: 717‑720, 1987.

 

Brum, G. and Ríos, E.  Intramembrane charge movement in frog skeletal muscle fibres.  Properties of Charge 2.  J. Physiol. (London), 387: 489‑517, 1987.

 

Brum, G., Stéfani, E. and Ríos, E.  Simultaneous measurements of Ca currents and intracellular Ca concentrations in single skeletal muscle fibres of the frog.  Can. J. Physiol. Pharmacol., 65: 681‑685, 1987.

 

Schneider, M.F., Ríos, E. and Melzer, W.  Determining the rate of calcium release from the                   sarcoplasmic reticulum in muscle fibers.  Biophys. J., 51: 1005‑1007, 1987.

 

Brum, G., Ríos, E. and Stéfani, E. (with an appendix by Brum, G., Ríos E. and Schneider, M.F.).  Effects of extracellular calcium on the calcium movements of excitation‑contraction coupling in skeletal muscle fibres.  J. Physiol. 398: 475‑505, 1988.

 

Brum, G., Fitts, R., Pizarro, G. and Ríos, E.  Mobile charges of the skeletal muscle membrane require calcium to function as voltage sensors of excitation‑contraction coupling.  J. Physiol. 398: 441‑473, 1988.  

 

Ríos, E.  Excitation contraction coupling in skeletal muscle.  Problems and advances.  Boletín de la Sociedad de Biofísicos Latino Americanos.  2: 4‑5, 1988 (in Spanish).

 

Pizarro, G., Brum, G., Fill, M., Fitts, R., Rodríguez, M., Uribe, I. and Ríos, E.  The voltage sensor of skeletal muscle excitation‑contraction coupling.  A comparison with Ca channels.  "The calcium channel:  Structure, Function and Implications".  Edited by M. Morad, W. Nayler, S. Kazda, M. Schramm. pp 138‑158.  Springer‑Verlag, Heidelberg, 1988.

 

Ríos, E. and Pizarro, G.  The voltage sensors and calcium channels of excitation‑

      contraction coupling.  News in Physiological Sciences, 3: 223‑227, 1988.

 

Pizarro, G., Fitts, R., Uribe, I. and Ríos, E.  The voltage sensor of excitation‑ contraction coupling in skeletal muscle.  Ion‑dependence and selectivity.  J. Gen. Physiol.  94: 405‑428, 1989.

 

Bean, B.P. and Ríos, E.  Non‑linear charge movement in the membranes of mammalian cardiac ventricular cells.  J. Gen. Physiol. 94: 65‑93, 1989.

 

Ríos, E., Pizarro, G., Uribe, I. and Fitts, R.  A third role for calcium in excitation‑ contraction coupling.  In: "Transduction in Biological Systems".  Edited by C.  Hidalgo, J. Bacigalupo, E. Jaimovich an J. Vergara, pp 385‑400.  Plenum Press, New York, 1990.

 

Csernoch, L., G. Pizarro , I. Uribe, M. Rodríguez and E. Ríos.  Interfering with Ca release suppresses I, the delayed component of intramembrane charge movement in skeletal muscle.  J. Gen. Physiol. 97: 845‑884, 1991.

   

García, J., E. Ríos and E. Stéfani.  Effects of the calcium buffer EGTA on the delayed charge of skeletal muscle.  J. Gen. Physiol. 97: 885‑896, 1991.

 

Pizarro, G., L. Csernoch, I. Uribe, M. Rodriguez and E. Ríos.  The relationship between Q and Ca release from the sarcoplasmic reticulum in skeletal muscle.  J. Gen.

Physiol. 97: 913‑947, 1991.

 

Ríos, E. and G. Pizarro.  The voltage sensor of E‑C coupling in skeletal muscle.  Physiological Reviews, 71: 849-908, 1991.

 

Ríos, E., J. Ma and A. González.  The mechanical model of excitation‑contraction

     coupling in skeletal muscle.  Journal of Muscle Research and Cell Motility, 12:  127-135, 1991.

 

Hosey, M.M., Brawley, R.M., Chang, C.F., Gutiérrez, L.M., Mundiña‑Weilenmann, C., Ma, J. and Ríos, E.  Phosphorylation and regulation of calcium channels by multiple protein kinases.  In:  "NATO Advance Research Workshop on Intracellular Regulation of Ion Channels".  Edited by Martin Morad.  Springer‑Verlag, 1991.

 

Ma, J., Mundiña de Weilenmann, C., Hosey, M. and Ríos, E.  Dihydropyridine‑sensitive skeletal muscle Ca channels in polarized bilayers.  I. Kinetics and voltage dependence of gating.  Biophys. J. 60: 890‑901, 1991.

 

Mundiña‑Weilenmann, C., Ma, J., Ríos, E. and Hosey, M.  Dihydropyridine‑sensitive skeletal muscle Ca channels in polarized bilayers.  II. Effects of phosphorylation by cAMP‑dependent protein kinase.  Biophys. J. 60: 902‑909, 1991.

 

Ma, J., Gutiérrez, L., Hosey, M. and Ríos, E.  Dihydropyridine‑sensitive skeletal muscle Ca channels in polarized bilayers.  III. Effects of phosphorylation by protein kinase C.  Biophys. J. 63: 639‑647, 1992.

 

Ríos, E., Pizarro, G. and E. Stéfani.  Charge movements and the nature of signal transduction in skeletal muscle excitation‑contraction coupling.  Annual Review of Physiology, 54: 109‑133, 1992.

 

Csernoch, L., Pizarro, G., Garcia, J., Szucs, G., Stefani, E. and Ríos, E.  Effects of sarcoplasmic calcium release on intramembrane charge movement in skeletal muscle.  In: "Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle".  Edited by G.B. Frank et al. pp 137-148.  Plenum Press, New York, 1992.

 

Pizarro, G., Csernoch, L. and Ríos, E.  Differential effects of tetracaine on two kinetic components of calcium release in frog skeletal muscle fibres.  J. Physiol. 457: 525‑538, 1992.

 

Shirokov, R., Levis, R., Shirokova, N. and Ríos, E.  Two classes of gaing current from L‑type a channels in guinea pig ventricular myocytes.  J. Gen. Physiol. 99: 863‑895, 1992.

 

González, A. and Ríos, E.  Perchlorate enhances transmission in skeletal muscle excitation-contraction coupling.  J. Gen. Physiol. 102: 373-421, 1993.

 

Ma, J., Anderson, K., Shirokov, R., Levis, R., González, A., Karhanek, M., Hosey, M.M., Meissner, G. and Ríos, E.  Effects of perchlorate on the molecules of excitation-contraction coupling of skeletal and cardiac muscle.  J. Gen. Physiol. 102: 423-448, 1993.

 

Rios, E., Karhanek, M., Ma, J. and González, A.  An allosteric model of the molecular interactions of excitation-contraction coupling in skeletal muscle.  J. Gen. Physiol. 102: 449-481, 1993.

 

Shirokov, R., Levis, R., Shirokova, N. and Ríos, E.  Ca2+-dependent inactivation of cardiac L-type Ca2+ channels does not affect their voltage sensor.  J. Gen. Physiol. 102: 1005-1030, 1993.

 

Shirokova, N., Pizarro, G. and Ríos, E.  A damped oscillation in the intramembranous charge movement and calcium release flux of frog skeletal muscle fibers.  J. Gen. Physiol. 104: 449-477, 1994.

Ríos, E.  Reining in Calcium Release.  Biophys. J. 67: 7-9, 1994.

 

Shirokova, N., González, A., Ma, J., Shirokov, R. and Ríos, E.  Properties and roles of an intramembranous charge mobilized at high voltages in skeletal muscle.  J.  Physiol. 486: 385-400, 1995.

 

Tsugorka, A., Ríos, E., and Blatter, L.A.  Imaging elementary events of calcium release in skeletal muscle cells.  Science 269:1723-1726, 1995.

 

Chien, A.J., Zhao, X., Shirokov, R.E., Puri, T.S., Chang, C.F., Sun, D., Ríos, E., and Hosey, M.  Roles of a Membrane-localized  Subunit in the Formation and Targeting of Functional L-type Ca2+ Channel.  J. Biol. Chem. 270:30036-30044, 1995.

Ríos, E.  Homeostasis of Ca2+ in skeletal muscle.  In "Nerve‑Muscle Function: Bioelectro‑ Chemistry, Mechanism, Energetics and Control".  Edited by G. Milazzo.  NATO‑ASI, Roma, 1995.

 

Ríos, E., González, A., Karhanek, M., Ma, J., Shirokov, R., Pizarro, G., Csernoch, L., Fitts, R., Uribe, I., Hosey, M.M.  Excitation‑contraction coupling in skeletal and cardiac muscle.  In: "Nerve‑Muscle Function: Bioelectro‑ Chemistry, Mechanism, Energetics and Control".  Edited by G. Milazzo.  NATO‑ASI, Roma.  1995.

 

Ríos, E.  Excitation contraction coupling in skeletal muscle.  In:  "Biofísica". Edited by  Ramón Latorre, Universidad de Sevilla Press. 1996.

 

Ríos, E.  Optical techniques for detection of intracellular calcium.  In:  "Biofísica".  Edited by  Ramón Latorre, Universidad de Sevilla Press.  1996.

 

Shirokova, N., García, J., Pizarro, G. and Ríos, E.  Ca2+ release from the sarcoplasmic reticulum compared in amphibian and mammailian skeletal muscle.  J. Gen. Physiol. 107:1-18, 1996.

 

Shirokova, N. and Ríos, E.  Caffeine enhances intramembranous charge movement in frog skeletal muscle by increasing cytoplasmic Ca2+ concentration.  J. Physiol. 493:341-356, 1996.

 

Shirokova, N. and Ríos, E.  Activation of Ca2+ release by caffeine and voltage in frog skeletal muscle.  J. Physiol. 493:317-339, 1996.

 

J. Chien, K.M. Carr , R.E. Shirokov, E. Rios and M.M. Hosey Identification of Palmitoylation Sites within the L‑type Calcium Channel 2a Subunit and Effects on Channel Function.  J. Biol. Chem. 271 26465‑26468, 1996 .

 

Meissner, G., Ríos, E., Tripathy, A., and Pasek, D.A.  Regulation of skeletal muscle Ca2+ release channel (ryanodine receptor) by Ca2+ and monovalent cations and anions.  J. Biol. Chem., 272:1628-1638, 1997.

 

Ríos, E. and Stern, M.  Calcium in Close Quarters: Microdomain feedback in excitation-contraction coupling and other cell biological phenomena.  Ann. Rev. Biophys. Biomolec. Struct.,26:47‑82, 1997.

 

Blatter, L.A., Hüser, J and Ríos, E.  Sarcoplasmic reticulum Ca2+ release flux underlying Ca2+ sparks in cardiac muscle. PNAS 94: 4176‑4181, 1997. 

 

Pizarro, G., Shirokova, N., Tsugorka, A. and Ríos, E.  “Quantal” calcium release operated by membrane voltage in frog skeletal muscle. J. Physiol. 501: 289‑303, 1997.

Ferreira, G., Yi, J., Ríos, E., and Shirokov, R.  Ion-dependent inactivation of barium current through L-type calcium channels.  J. Gen. Physiol. 109:449‑462, 1997.

 

Shirokova N and Ríos, E.     Small event Ca2+ release: a probable precursor of Ca2+ sparks in frog skeletal muscle.     J. Physiol. 502: 3‑11, 1997.

 

Stern, M.D., G. Pizarro and E. Ríos.  A local control model of excitation-contraction coupling in skeletal muscle.  J. Gen. Physiol. 110: 415-440, 1997.  

 

Ríos, E. and Stern, M.  Calcium in Close Quarters: Microdomain feedback in excitation-contraction coupling and other cell biological phenomena.  Ann. Rev. Biophys. Biomolec. Struct.,26:47‑82. 1997.

 

Shirokov, R., Ferreira, G., Yi, J. and Ríos,E.  Inactivation of gating currents of L-type  calcium channels.  Specific role of the 2 subunit.  J. Gen. Physiol. 111:807-823, 1998.

 

Zhou, J., Cribbs, L., Yi, J., Shirokov, R., Perez-Reyes, E. and Ríos, E.   Molecular cloning and functional expression of a skeletal muscle dihydropyridine receptor form Rana catesbeiana.  J. Biol. Chem.  273:25503-25509, 1998.

 

Shirokova, N., J. García and E. Ríos.  Local calcium release in mammalian skeletal muscle.  J. Physiol. 812:377-384, 1998.

 

Cheng, H., L.S. Song, N. Shirokova, A Gonzalez, e.G. Lakatta , E. Ríos and M.D. Stern.  Amplitude distribution of calcium sparks in confocal images.  Theory and studies with an automatic detection method.  Biophys. J. 76: 606-617, 1999.

 

Mejía-Alvarez, R., C. Kettlun, E. Ríos, M.D. Stern and M. Fill.  Unitary Ca2+ Current through Cardiac Ryanodine Receptor Channels under Quasi‑Physiological Ionic Conditions.    J. Gen. Physiol. 113: 177‑186, 1999.

 

Stern, M.D., L. Song, H. Cheng, J. Sham, HT Yang, K.R. Boehler and E. Ríos.  Local control models of cardiac excitation-contraction coupling: a possible role for allosteric interactions between ryanodine receptors. J. Gen. Physiol. 113(3):469-89, 1999.

 

Stern, M.D., L. Song, H. Cheng, J. Sham, HT Yang, K.R. Boehler and E. Ríos.  Local control models of cardiac excitation-contraction coupling: a possible role for allosteric interactions between ryanodine receptors. J. Gen. Physiol. 113: 469-490, 1999.

 

Shirokova, N., A. Gonzalez, W.G. Kirsch, E. Ríos, G. Pizarro, M.D. Stern and H. Cheng. Calcium Sparks: release packets of uncertain origin and fundamental role. J. Gen. Physiol. 113: 377-384, 1999.

 

Rios, E., M.D. Stern, A. Gonzalez, G. Pizarro, and N. Shirokova.   Calcium release flux underlying Ca2+ sparks of frog skeletal muscle.  J. Gen. Physiol. 114:31‑48.1999.

 

Shirokova, N., R. Shirokov, D. Rossi, A. Gonzalez, W.G. Kirsch, J. Garcia, V. Sorrentino and E. Ríos.  Spatially segregated control of Ca2+ release in developing skeletal muscle.  J. Physiol. 521: 483-495. 1999.

 

      Shirokova, N., A. Gonzalez, W.G. Kirsch, E. Ríos, G.Pizarro, M.D. Stern and H. Cheng.   Calcium Sparks: release packets of          uncertain origin and fundamental role.    J. Gen. Physiol. 113:377-384, 1999.

 

2000 to date  (Rush University, Chicago) 

   The spark and its ember: separately gated components of Ca release in skeletal muscle.  Adom Gonzalez, W.G. Kirsch, N. Shirokova, G. Pizarro, M.D. Stern and E. Rios. J. Gen. Physiol. 115:139-158. 2000.

    Involvement of multiple intracellular release channels in calcium sparks of skeletal muscle. A. González, W.G. Kirsch, N. Shirokova, G. Pizarro, G. Brum, I.N. Pessah, M.D. Stern, H. Cheng and E. Ríos. PNAS USA, 97:4380-4385. 2000.

    Fast imaging in three dimensions resolves extensive sources of Ca sparks in frog skeletal muscle. G. Brum, A. Gonzalez, J. Rengifo, N. Shirokova and E. Ríos. J. Physiol. 2000.

    A preferred amplitude of Calcium Sparks in skeletal muscle. E. Ríos, N. Shirokova, W.G. Kirsch, G. Pizarro, M.D. Stern, H.Cheng, and A. González. Biophys. J. 80: 169-183, 2001.  

    Excitation-Contraction Coupling in Skeletal Muscle. Adom González and Eduardo Ríos. In "Molecular Control of Striated Muscle Contraction".  J. Solaro and E. Moss, editors.  

    Thermodynamically irreversible gating of ryanodine receptors in situ, Revealed by Stereotyped Duration of Release in Ca2+ Sparks. Shi-Qiang Wang, Long-Sheng Song, Le Xu, Gerhard Meissner, Edward G. Lakatta, Eduardo Ríos†, Michael D. Stern, Heping Cheng. Biophys. J.  83: 242-251. 2002.

    Ca2+ release flux underlying Ca2+ transients and Ca2+ sparks in skeletal muscle. Eduardo Ríos and Gustavo Brum.  Frontiers in Bioscience 7, d1195-1211,  2002

    Intracellular Ca2+ release as irreversible Markov process. J. Rengifo, R. Rosales, A. González, H. Cheng, M.D. Stern, and E. Ríos. Biophys J. 83:2511-2521.  2002.

    Two components of voltage-dependent inactivation in Cav 1.2 channels revealed by its gating currents. G Ferreira, E. Ríos and N. Reyes.   Biophys. J. 84:3662-78.  2003.

    Ca2+ sparks and embers of mammalian muscle.  Properties of the sources. J. Zhou, G. Brum, A. González, B.S. Launikonis, M.D. Stern, E. Ríos.  J. Gen. Physiol.  122:95-114.   2003. 

    Unitary Ca current through mammalian cardiac and amphibian skeletal muscle ryanodine receptor channels under near-physiological ionic conditions. C Kettlun, A González, E. Ríos and M Fill. J. Gen. Physiol. 122: 407-417.  2003.

    The Quantal Nature of Ca2+ Sparks and in situ operation of the ryanodine receptor array in cardiac cells.  SQ Wang, MD Stern, E Ríos, H Cheng.   P.N.A.S. USA 101: 3979-3984. 2004. 

    Regulation of Ca2+ sparks by Ca2+ and Mg2+ in mammalian and amphibian muscle. An RyR isoform-specific role in excitation-contraction coupling?  Zhou J, Launikonis BS, Rios E, Brum G.  J Gen Physiol. 124: 409-28. 2004 

    The elementary events of Ca2+ release elicited by membrane depolarization in mammalian muscle.  Csernoch L, Zhou J, Stern MD, Brum G, Rios E.  J. Physiol. 557:43-58. 2004 

    How source content determines intracellular Ca2+ release kinetics. Simultaneous measurement of [Ca2+] transients and [H+]  displacement in skeletal muscle. G. Pizarro, E Ríos.    J. Gen. Physiol.  124:239-58. 2004.

    Control of dual isoforms of Ca2+ release channels in muscle.E Ríos, J. Zhou.    Biol. Res.  37:583-592. 2004.

    Confocal imaging of [Ca2+] in  cellular organelles by SEER, Shifted Excitation and Emission Ratioing of fluorescence. Bradley S Launikonis, Jingsong Zhou, Leandro Royer, Thomas R Shannon, Gustavo Brum, and Eduardo Ríos J Physiol , 2005, 

    Concerted vs. Sequential. Two Activation Patterns of Vast Arrays of Intracellular Ca2+ Channels in Muscle. Zhou, J., et al.   J. Gen. Physiol. 126:301-9, 2005.  Cover article.

    A probable role of dihydropyridine receptors in repression of Ca2+ sparks, demonstrated in cultured mammalian muscle. Zhou, J., et al.  Am. J. Physiol. (Cell). 290:C539-C553. 2006.

    Depletion “skraps” and dynamic buffering inside the cellular calcium store. Launikonis, B.S. et al. Proc.Nat.Acad.Sci. USA.  103:2982-2987. 2006.

    The Changes in Ca2+ Sparks Associated with Measured Modifications of Intra-store Ca2+ Concentration in Skeletal Muscle.  Launikonis, B.S. et al. J Gen Physiol.  128:45-54.  2006.

    The elusive role of store depletion in the control of intracellular calcium release.  Rios E, Launikonis BS, Royer L, Brum G, Zhou J. J Muscle Res Cell Motil. 27:337-50. 2006

    Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Curran J, Hinton MJ, Ríos E, Bers DM, Shannon TR.  Circ Res. 2007 Feb 16;100(3):391-8.

    Ca2+ sparks operated by membrane depolarization require isoform 3 ryanodine receptor channels in skeletal muscle. Pouvreau S, Royer L, Yi J, Brum G, Meissner G, Ríos E, Zhou J.  Proc Natl Acad Sci U S A.  104:5235-40. 2007

    Store-operated Ca2+ entry during intracellular Ca2+ release in mammalian skeletal muscle. Launikonis BS, Ríos E.   J Physiol. 2007 Aug 15;583:81-97.

    Calcium-dependent inactivation terminates calcium release in skeletal muscle of amphibians. Ríos E, Zhou J, Brum G, Launikonis BS, Stern MD. J Gen Physiol. 2008 Apr;131(4):335-48.

    A pH-stabilizing role of voltage-gated proton channels in IgE-mediated activation of human basophils. Musset B, Morgan D, Cherny VV, MacGlashan DW Jr, Thomas LL, Ríos E, DeCoursey TE. Proc Natl Acad Sci U S A.; 105:11020-5. 2008.

    Evolution and modulation of intracellular calcium release during long-lasting, depleting depolarization in mouse muscle. Royer L, Pouvreau S, Ríos E.     J Physiol. 586:4609-29. 2008

     Deconstructing calsequestrin. Complex buffering in the calcium store of skeletal muscle. Royer L, Ríos E. J Physiol.  587:3101-11. 2009.

    The cell boundary theorem: a simple law of the control of cytosolic calcium concentration. Ríos E. J Physiol Sci. 60:81-84. 2010

    Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis. Zhou J, Yi J, Fu R, Liu E, Siddique T, Ríos E, Deng HX. J Biol Chem. 285:705-12. 2010 

    Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis.  Morgan D, Capasso M, Musset B, Cherny VV, Ríos E, Dyer MJ, DeCoursey TE. Proc Natl Acad Sci U S A.  106:18022-7. 2009

      Calsequestrin, triadin and more: the molecules that modulate calcium release in cardiac and skeletal muscle. Ríos E, Györke S. J Physiol. 587:3069-70. 2009

      Indo-1 derivatives for local calcium sensing. M. Bannwarth, IR Correa, M Sztretye, S Pouvreau, C Fellay, A Aebischer, L Royer, E Rios, K Johnsson. ACS Chemical Biology 4: 3, 2009.  Cover Article.

      RyR1 Expression and the Cell Boundary TheoremRíos E. J Biol Chem. 285: le13.  2010.     

      Paradoxical buffering of calcium by calsequestrin demonstrated for the calcium store of skeletal muscle.  Royer L, Sztretye M, Manno C, Pouvreau S, Zhou J, Knollmann BC, Protasi F, Allen PD, Ríos E.  J Gen Physiol. 136:325-38.2010 

     Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes.  Santiago DJ, JW Curran, DM Bers, WJ Lederer, MD Stern, E Ríos, TR Shannon. Biophys J. 98:2111-2120. 2010.

     Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis.  Zhou J, Yi J, Fu R, Liu E, Siddique T, Ríos E, Deng HX.    J. Biol. Chem. 285:705-712. 2010.

     Mitochondrial calcium uptake regulates rapid calcium transients in skeletal muscle during excitation-contraction (E-C) coupling. Yi, J, C Ma, Y Li, N Weisleder, E Ríos, J Ma and J Zhou.   J. Biol. Chem. 286:32436-32443. 2011.

     D4cpv-calsequestrin: a sensitive ratiometric biosensor accurately targeted to the calcium store of skeletal muscle.  Sztretye, M, J Yi, L Figueroa, J Zhou, L Royer and E RíosJ. Gen. Physiol. 138:211-229.  2011. 

     Measurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca2+ release in skeletal muscle.  Sztretye, M, J Yi, L Figueroa, J Zhou, L Royer, P Allen, G Brum and E Ríos .  J. Gen. Physiol. 138:231-247.  2011. 

    Properties of Ca2+ sparks revealed by four-dimensional confocal imaging of cardiac muscle. Shkryl, V, Blatter, L and E Rios.  J. Gen. Physiol. 139:189-207  2012.  Cover Article.

    Synthetic localized calcium transients directly probe signaling mechanisms in skeletal muscle.  Figueroa, L, VM Shkryl, J Zhou, C Manno, A Momotake, G Brum , LA Blatter, GCR Ellis-Davies and E Ríos .   .  J. Physiol.  590: 1389-1411. 2012.  Cover Article.

   El¨"cuplón", unidad funcional del acoplamiento contráctil.  E Rios.  An Facultad Med (Univ. Repúb. Urug.). 2014; 1(1):4-28.  2014.

  A better method to measure total calcium in biological samples yields immediate payoffs. Manno C, Ríos E. J Gen Physiol.  Mar;145(3):167-71. 2015.


   The couplonopathies: A comparative approach to a class of diseases of skeletal and cardiac muscle. Ríos E, Figueroa L, Manno C, Kraeva N, Riazi S. 2015. Viewpoint. J Gen Physiol. 2015 Jun;145(6):459-74. doi:0.1085/ jgp.201411321. PMID: 26009541..